
Texas A&M Drug Discovery Center
The primary focus of the Texas A&M Drug Discovery Center is to guide targets identified by investigators through the drug discovery process and to facilitate the transition from basic research studies to drug discovery. In the past five years, we have acquired over $2 million in instrumentation to aid in drug discovery research. By consolidating resources within Texas A&M, services or consultations are available for nearly all preclinical applications in drug discovery. There are three main areas of focus within the center:
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Facilities to support the identification and optimization of peptide therapeutics are available including phage selections, synthesis, and a variety of characterization techniques.
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We have a customizable automated screening platform made up of the largest Access Workstation in Texas and will aid in all stages of the high throughput screening process, from assay development to lead identification.
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A core focused on small molecule drug development is targeted to provide resources and consultations for synthetic methods, assay design, and computer-aided drug design.
Small Molecule Drug Development
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Structure-Based Drug Design
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Consultations
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Large Scale Synthesis
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Assay Design and Probe Synthesis
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Molecular Modeling
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Virtual Screening/Docking
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Early prediction of PK/PD and ADMET
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Characterization Techniques
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Biolayer Interferometry
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Surface Plasmon Resonance
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AlphaScreen/AlphaLISA
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Fluorescence Polarization
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Peptide Therapeutics
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Selections using phage-displayed peptide libraries (>109 sequences per library)
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Option for insertion of noncanonical amino acids within libraries
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Linear and Macrocyclic peptides
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Customizable peptide synthesis
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25 µmol – 1.2 mmol scale
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Peptide Characterization Techniques
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Biolayer Interferometry
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Surface Plasmon Resonance
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AlphaScreen/AlphaLISA
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Fluorescence Polarization
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Automated Screening Platforms
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Access Workstation – Largest Unit in Texas!
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Echo 650 Liquid Handler
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Microplate Washer
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Cytomat 10C Incubator
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Neo2 Plate Reader
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Integra Assist Liquid Handler
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Customizable Assay Development Services
For service-related inquiries, please contact:
Joshua Trae Hampton
Research Assistant Professor
Manager, Texas A&M Drug Discovery Center
PhD, Chemistry
Texas A&M University, 2023
BS, Biochemistry
University of Dallas, 2018
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