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PUBLICATIONS
2025
2-Cyanopyrimidine-Containing Molecules for N-Terminal Selective Cyclization of Phage-Displayed Peptides
2025
2024
2024
Computational Model-Assisted Development of a Nonenzymatic Fluorescent Glucose-Sensing Assay
Prioritization of Eleven-Nineteen-Leukemia Inhibitors as Orally Available Drug Candidates for Acute Myeloid Leukemia
Directed Evolution of Candidatus Methanomethylophilus alvus Pyrrolysyl-tRNA Synthetase for the Genetic Incorporation of Two Different Noncanonical Amino Acids in One Protein
SARS-CoV-2 Main Protease Inhibitors That Leverage Unique Interactions with the Solvent Exposed S3 Site of the Enzyme
Diversification of Phage-Displayed Peptide Libraries with Noncanonical Amino Acid Mutagenesis and Chemical Modification
Azapeptides with unique covalent warheads as SARS-CoV-2 main protease inhibitors
Kaustav Khatua, Yugendar R. Alugubelli, Kai S. Yang, Veerabhadra R Vulupala, Lauren R. Blankenship, Demonta Coleman, Sandeep Atla, Sankar P. Chaki, Chia-Chuan D. Cho, Shivangi Sharma, Erol C. Vatansever, Yuying Ma, Ge Yu, Benjamin W. Newman, Shiqing Su and Wenshe R. Liu*, “Azapeptides with Unique Covalent Warheads as SARS-CoV-2 Main Protease Inhibitors”, Antiviral Research 225, 2024, 105874.
Leveraging a Phage-Encoded Noncanonical Amino Acid: A NovelPathway to Potent and Selective Epigenetic Reader ProteinInhibitors
Peng-Hsun Chase Chen, Xuejiao S. Guo, Hanyuan E. Zhang, Gopal K. Dubey, Zhi Z. Geng, Carol A. Fierke, Shiqing Xu, J. Trae Hampton and Wenshe R. Liu*, “Leveraging a Phage-Encoded Noncanonical Amino Acid: A Novel Pathway to Potent and Selective Epigenetic Reader Protein Inhibitors”, ACS Cent. Sci., 2024, 10, 782-792.
BRD4354 Is a Potent Covalent Inhibitor against the SARS-CoV-2 Main Protease
Yan J. Sheng, Syuan-Ting A. Kuo, Tingyuan Yang, Hanyuan E. Zhang, David H. Russell, Xin Yan, Shiqing Xu, Wenshe R. Liu and Carol A. Fierke*, “BRD4354 Is a Potent Covalent Inhibitor against the SARS-CoV-2 Main Protease”, Biochemistry, 2024, 63, 402-406.
Discovery of First-in-Class PROTAC Degraders of SARS-CoV‑2 MainProtease
Yugendar R. Alugubelli, Jing Xiao, Kaustav Khatua, Sathish Kumar, Long Sun, Yuying Ma, Xinyu R. Ma, Veerabhadra R. Vulupala, Sandeep Atla, Lauren R. Blankenship, Demonta Coleman, Xuping Xie, Benjamin W. Newman, Wenshe R. Liu and Shiqing Xu*, “Discovery of First-in-Class PROTAC Degraders of SARS-CoV-2 Main Protease”, J. Med. Chem., 2024, 67, 6495-6507.
2023
An amber-encoding helper phage for more efficient phage display of noncanonical amino acids
J. Trae Hampton, Chia-Chuan D. Cho, Demonta D. Coleman, Zhi Z. Geng, Peng-Hsun C. Chen, Gopal K. Dubey, Lauralee D. Sylvain, Shiqing Xu and Wenshe R. Liu*, “An Amber-encoding Helper Phage for More Efficient Phage Display of Noncanonical Amino Acids”, Nucleic Acids Research, 2023, Vol. 51, No. 13, 6566-6577.
2023
A Systematic Survey of Reversibly Covalent Dipeptidyl Inhibitors of the SARS-CoV-2 Main Protease
Zhi Z. Geng, Sandeep Atla, Namir Shaabani, Veerabhadra R. Vulupala, Kai S. Yang, Yugendar R. Alugubelli, Kaustav Khatua, Peng-Hsun Chen, Jing Xiao, Lauren R. Blankenship, Xinyu R. Ma, Erol C. Vantansever, Chia-Chuan D. Cho, Yuying Ma, Robert Allen, Henry Ji, Shiqing Xu and Wenshe R. Liu*, “A Systematic Survey of Reversibly Covalent Dipeptidyl Inhibitors of the SARS-CoV-2 Main Protease”, J. Med. Chem. 2023, 66, 3, 449-455.
A Novel Y-Shaped, S–O–N–O–S-Bridged Cross-Link between Three Residues C22, C44, and K61 Is Frequently Observed in the SARS-CoV-2 Main Protease
Kai S. Yang, Lauren R. Blankenship, Syuan-Ting Alex Kuo, Yan J. Sheng, Pringwei Li, Carol A. Fierke, David H. Russell, Xin Yan, Shiqing Xu* and Wenshe R. Liu*, “A Novel Y-Shaped, S-O-N-O-S-Bridged Crosslink between Three Residues C22, C44, and K61 Is a Redox Switch of the SARS-CoV-2 Main Protease”, ACS Chem. Biol 2023, 18, 3, 449-455.
Novel Regioselective Approach to Cyclize Phage-Displayed Peptides in Combination with Epitope-Directed Selection to Identify a Potent Neutralizing Macrocyclic Peptide for SARS-CoV-2
J. Trae Hampton, Tyler J. Lalonde, Jeffery M. Tharp, Yadagiri Kurra, Yugendar R. Alugubelli, Christopher M. Roundy, Gabriel L. Hamer, Shiqing Xu and W. R. Liu*, “Novel Regioselective Approach to Cyclize Phage-Displayed Peptides in Combination with Epitope-Directed Selection to Identify a Potent Neutralizing Macrocylic Peptide for SARS-CoV-2”, ACS Chem. Biol., 2022, 17, 2911-2922.
2022
Phage-assisted, active site-directed ligand evolution of apotent and selective histone deacetylase 8 inhibitor
Jared S. Morse, Yan J. Sheng, J. Trae Hampton, Lauralee D. Sylvain, Sukant Das, Yugendar R. Alugubelli, Peng-Hsun Chase Chen, Kai S. Yang, Shiqing Xu, Carol A. Fierke and W. R. Liu*, “Phage-assisted, Active Site-Directed Ligand Evolution of a Potent and Selective Histone Deacetylase 8 Inhibitor.”, Protein Science, 2022, 31:e4512.
MPI8 is Potent against SARS-CoV-2 by Inhibiting Dually and Selectively the SARS-CoV-2 Main Protease and the Host Cathepsin L**
Xinyu R. Ma, Yugendar R. Alugubelli, Yuyin Ma, Erol C. Vatansever, Danielle A. Scott, Yuchen Qiao, Ge Yu, Shiqing Xu*, and W. R. Liu*, “MPI8 is Potent Against SARS-CoV-2 by Inhibiting Dually and Selectively the SARS-CoV-2 Main Protease and the Host Cathepsin L”, Angew. Chem. 2022, 134, , 192-204.
2022
Titelbild: A Reversible Chemogenetic Switch for Chimeric Antigen Receptor T Cells (Angew. Chem. 10/2022)
Wenyue Cao, Zhi Zachary Geng, Na Wang, Quan Pan, Shaodong Guo, Shiqing Xu, Jianfeng Zhou* and W. R. Liu*, “A Reversible Chemogenetic Switch for Chimeric Antigen Receptor T Cell”, Angew. Chem. 2022, 134, , 192-204.
A systematic exploration of boceprevir-based main protease inhibitors as SARS-CoV-2 antivirals
Yugendar R. Alugubelli, Zhi ZacharyGeng, Kai S. Yang, Namir Shaabani, Kaustav Khatua, Xinyu R. Ma, Erol C. Vatansever, Chia-Chuan Cho, Yuying Ma, Jing Xiao, Lauren R. Blankenship, Ge Yu, Banumathi Sankaran, Pingwei Li, Robert Allen, Henry Ji, Shiqing Xu and W. R. Liu*, “A Systematic Exploration of Boceprevir-based Main Protease Inhibitors as SARS-CoV-2 Antivirals.”, Eur. J. Med. Chem., 2022, 240,114596.
A multi-pronged evaluation of aldehyde-based tripeptidyl main protease inhibitors as SARS-CoV-2 antivirals
Yuying Ma, Kai S. Yang, Zhi Zachary Geng, Yugendar R. Alugubelli, Namir Shaabani, Erol C. Vatansever, Xinyu R. Ma, Chia-Chuan Cho, Kaustav Khatua, Jin Xiao, Lauren R. Blankenship, Ge Yu, Banumathi Sankaran, Pingwei Li, Robert Allen, Henry Ji, Shiqing Su and W. R. Liu*, “A Multi-pronged Evaluation of Aldehyde-based Tripeptidyl Main Protease Inhibitors as SARS-CoV-2 Antivirals”, Eur. J. Med. Chem., 2022, 240,114570.
Taf2 mediates DNA binding of Taf14
Brianna J. Klein, Jordan T. Feigerle, Jibo Zhang, Christopher C. Ebmeier, Lixin Fan, Rohit K. Singh, Wesley W. Wang, Lauren R. Schmitt, Thomas Lee, Kirk C. Hansen, Wenshe R. Liu, Yun-Xing Wang, Brian D. Strahl, P. Anthony Weil, and Tatiana G. Kutateladze*, “Taf2 Mediates DNA Binding of Taf14”, Nat. Commun. 2022, 13(1), 3177.
Resveratrol Binds Nuclear Receptor 4A1 (NR4A1) and Acts as an NR4A1 Antagonist in Lung Cancer Cells
Lei Zhang, Greg Martin, Jumaravel Mohankumar, Joshua Trae Hampton, Wenshe R. Liu and Stephen Safe*, “Reseratrol Binds Nuclear Receptor 4A1 (NR4A1) and Acts as an NR4A1 Antagonist in Lung Cancer Cells”,Mol. Pharmacol., 2022, 102(2), 80-91. doi: 10.1124/molpharm.121.000481.
Accurate Mass Identification of an Interfering Water Adduct and Strategies in Development and Validation of an LC-MS/MS Method for Quantification of MPI8, a Potent SARS-CoV-2 Main Protease Inhibitor, in Rat Plasma in Pharmacokinetic Studies
Yang Wang, Huan Xie, Yugendar R. Alugubelli, Yuying Ma, Shiqing Xu, Jing Ma, Wenshe R. Liu and Dong Liang*, “Accurate Mass Identification of an Interfering Water Adduct and Strategies in Development and Validation of al LC-MS/MS Method for Quantification of MPI8, a Potent SARS-CoV-2 Main Protease Inhibitor, in Rat Plasma in Pharmacokinetic Studies”, Pharmaceuticals. 2022, 15(6), 676. doi: 10.3390/ph15060676.
An Enhanced Hybrid Screening Approach to Identify Potent Inhibitors for the SARS-CoV-2 Main Protease From the NCI Compound Library
Shuhua G. Li, Kai S. Yang, Lauren R. Blankenship, Chia-Chuan D. Cho, Shiqing Xu, Hongbin Wang and W. R. Liu*, “An Enhanced Hybrid Screening Approac ot Identify Potent Inhibitors for the SARS-CoV-2 Main Protease From the NCI Compound Library”, Front. Chem., 2022, 10,816575.
A Designed, Highly Efficient Pyrrolysyl-tRNA Synthetase Mutant Binds o-Chlorophenylalanine Using Two Halogen Bonds
Erol C. Vatansever, Kai S. Yang, Zhi Zachary Geng, Yuchen Qiao, Pingwei Li, Shiqing Xu and W. R. Liu*, “A Designed, Highly Efficient Pyrrolysyl-tRNA Synthetase Mutant Binds o-Chlorophenylalanine Using Two Halogen Bonds”, J. Mol Biol, 2022, 167534.
The N-Terminal Carbamate is Key to High Cellular and Antiviral Potency for Boceprevir-Based SARS-CoV-2 Main Protease Inhibitors
Yugendar R. Alugubelli, Zhi Zachary Geng, Kai S. Yang, Namir Shaabani, Kaustav Khatua, Xinyu R. Ma, Erol C. Vatansever, Chia-Chuan Cho, Yuying Ma, Lauren Blankenship, Ge Yu, Banumathi Sankaran, Pingwei Li, Robert Allen, Henry Ji, Shiqing Xu and W. R. Liu*, “The N-Terminal Carbamate is Key to High Celluar and Antiviral Potency for Boceprevir-Based SARS-CoV-2 Main Protease Inhibitors”, bioRxiv 2022.
The P3 O-Tert-Butyl-Threonine is Key to High Cellular and Antiviral Potency for Aldehyde-Based SARS-CoV-2 Main Protease Inhibitors
Yuying Ma, Kai S. Yang, Zhi Zachary Geng, Yugendar R. Alugubelli, Namir Shaabani, Erol C. Vatansever, Xinyu R. Ma, Chia-Chuan Cho, Kaustave Khatua, Lauren Blankenship, Ge Yu, Banumathi Sankaran, Pingwei Li, Robert Allen, Henry Ji, Shiqing Xu and W. R. Liu*, “The P3 O-Tert-Butyl-Threonine is Key to High Celluar and Antiviral Potency for Aldehyde-Based SARS-CoV-2 Main Protease Inhibitors”, bioRxiv. 2022.
The Pyrrolysyl-tRNA Synthetase Activity can be Improved by a P188 Mutation that Stabilizes the Full-Length Enzyme
Chia-Chuan Cho, Lauren R. Blankenship, Xinyu Ma, Shiqing Xu and W. R. Liu*, “The Pyrrolysyl-tRNA Synthetase Activity can be Improved by a P188 Mutation that Stabilizes the Full-Length Enzyme”, J. Mol Biol, 2022, 434, 167453.
Evaluation of SARS-CoV‑2 Main Protease Inhibitors Using a Novel Cell-Based Assay
Wenyue Cao, Chia-Chuan Dean Cho, Zhi Zachary Geng, Namir Shaabani, Xinyu R. Ma, Erol C. Vtansever, Yugendar r. Alugubelli, Yuying Ma, Sankar P. Chaki, William H. Ellenburgm Kai S. Yang, Yuchen Qiao, Robert Allen, Benjamin W. Neuman, Henry Ji, Shiqing Xu and W. R. Liu*, “Evaluation of SARS-CoV-2 Main Protease Inhibitors Using a Novel Cell-Based Assay”, ACS Cent Sci. 2022, 8, 2, 192-204.
Repurposing Halicin as Potent Covalent Inhibitor for the SARS-CoV-2 Main Protease
K. S. Yang, Syuan-Ting Alex Kuo, Lauren R. Blankenshp, Zhi Zachary Geng, Shuhua G. Li, David H. Russell, Xin Yan, Shiqing Xu and W. R. Liu*, “Repurposing Halicin as Potent Covalent Inhibitor for the SARS-CoV-2 Main Protease”, Cur. Res. in Chem. Bio., 2022, 2, 100025.
2021
The Construction of a Genetically Encoded, Phage-Displayed Cyclic-Peptide Library
P-H C. Chen and W. R. Liu*, “The Construction of a Genetically Encoded, Phage-Displayed Cyclic-Peptide Library”, Chapter of Peptide Conjugation, Eds. W. M. Hussein, R. J. Stephenson & I. Toth, Springer Science+Business Media, LLC., 219-230.
2021
Discovery of Selective Small-Molecule Inhibitors for the ENL YEATS Domain
Xy R. Ma, L Xu, S. Xu, B. J. Klein, Hk Wang, S. Das, K. Li, K. S. Yang, S. Sohail, A. Chapman, T. G. Kutateladze, Xb. Shi and W. R. Liu*, “Discovery of Selective Small-Molecule Inhibitors for the ENL YEATS Domain”, J. Med. Chem. 2021, 64, 10997-11013.
Bepridil is potent against SARS-CoV-2 in vitro
E. C. Vatansever, K. S. Yang, K. C. Kratch, A. Drelich, C.-C. Cho, K. R. Kempaiah, J. C. Hsu, D. M. Mellott, S. Xu, C.-T. K. Tseng*, and Liu W.R.*, “Bepridil is Potent Against SARS-CoV-2 In Vitro”, Proc. Natl. Acad. Sci. U. S. A., 2021, 118(10): e2012201118.
2020
A Quick Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors
K. S. Yang, X. R. Ma, Y. Ma, Y. R. Alugubell, D. A. Scott, E. C. Vatansever, A. K. Drelich, B. Sankaran, Z. Z. Geng, L. R. Blankenship, H. E. Ward, Y. J. Sheng, J. C. Hsu, K. C. Kratch, B. Zhao, H. S. Hayatshsshi, J. Liu, P. Li, C. A. Fierke*, C.-T. K. Tseng*, S. Xu* and W. R. Liu*, “A Quick Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors”, ChemMedChem, 2021,DOI: 10.1002/cmdc.202000924 (VIP paper): 10.1002/cmdc.202000924 (VIP paper).
2020
Site Specific Lysine Acetylation of Histones for Nucleosome Reconstitution Using Genetic Code Expansion in Escherichia coli
C. M. Rowlett and W. R. Liu*, “Site Specific Lysine Acetylation of Histones for Nucleosome Reconstitution Using Genetic Code Expansion in Escherichia coli”, J. Vis. Exp. 2020, DOI: 10.3791/62113.
The Molecular Basis of Tight Nuclear Techering and Inactivation of cGAS
Baoyu Zhao, Pengbiao Xu, Chesley M. Rowlett, Tao Jing, Omkar Shinde, Yuanjiu Lei, a. Phillip West, Wenshe Ray Liu* & Pingwei Li*, “The Molecular Basis of Tight Nuclear Techering and Inactivation of cGAS”, Nature, 2020, https://doi.org/10.1038/s41586-020-2749-z.
A Speedy Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors
K. S. Yang, X. R. M, Y. Ma Y, Y. R. Alugubelli, D. A. Scott, E. C. Vatansever, A. K. Drelich, B. Sankaran, Z. Z. Geng, L. R. Blankenship, H. E. Ward, Y. J. Shen, J. C. Hsu, K. C. Kratch, B. Zhao, H. S. Hayatshsshi, J. Liu, P. Li, C. A. Fierke, C.-T. K. Tseng, S. Xu and W. R. Liu*, “A Speedy Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors”, BioRxiv, 2020, http://doi.org/10.1101/2020.07.28.223784.
Bepridil is Potent Against SARS-CoV-2 In Vitro
E. C. Vatansever, K. S. Yang, K. C. Kratch, A. Drelich, C.-C. Cho, D. M. Mellott, S. Xu, C.-T. K. Tseng, and W. R. Liu*, “Bepridil is Potent Against SARS-CoV-2 In Vitro”, BioRxiv, 2020, http://doi.org/10.1101/2020.05.23.112235
Stepwise Assembly of Turn-on Fluorescence Sensors in Multicomponent Metal–Organic Frameworks for in Vitro Cyanide Detection
J. Li, S. Yuan, J. S. Qin, J. Pang, P. Zhang, Y. Zhang, Y. Huang, H. F. Drake, W. R. Liu, and H. C. Zhou*, “Stepwise Assembly of “Turn-on” Fluorescent Sensors in Multicomponent Metal-Organic Frameworks for in vitro Cyanide Detection”, Angew. Chem. Int. Ed., 2020,59, 9319-9323. DOI: 10.1002/anie.202000702.
An amber obligate active site-directed ligand evolution technique for phage display
J. M. Tharp, J. T. Hampton, C. A. Reed, A. Ehnbom, P. C. Chen, J. S. Morse, Y. Kurra, L. M. Perez, S. Xu, W. R. Liu "An Amber Obligate Active Site-Directed Ligand Evolution Technique for Phage Display". Nat Commun. 2020, 11(1):1392.
Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019-nCoV
J. S. Morse, T. Lalonde, S Xu and W. R. Liu*, “Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019-nCoV”, ChemBioChem, 2020, 21(5):730-738 (VIP paper).
2019
Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation
B. J. Klein, S. M. Jang, C. Lachance, W. Mi, J. Lyu, S. Sakuraba, K. Krajewski, W. W. Wang, S. Sidoli, J. Liu, Y. Zhang, X. Wang, B. M. Warfield, A. J. Kueh, A. K. Voss, T. Thomas, B. A. Garcia, W. R. Liu, B. D. Strahl, H. Kono, W. Li, X. ShiX, J. Côté, T. G. Kutateladze."Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation". Nat Commun. 2019 Oct 17;10(1):4724. doi: 10.1038/s41467-019-12551-5. PubMed PMID: 31624313; PubMed Central PMCID: PMC6797804.
2019
A Genetically Encoded, Phage-Displayed Cyclic-Peptide Library
XS. Wang, P. C. Chen, J. T. Hampton, J. M. Tharp, C. A. Reed, S. K. Das, D. S. Wang,H. S. Hayatshahi, Y. Shen, J. Liu and W. R. Liu. "A Genetically Encoded, Phage-Displayed Cyclic-Peptide Library". Angew Chem Int Ed Engl. 2019 Oct 28;58(44):15904-15909. doi: 10.1002/anie.201908713. Epub 2019 Sep 9. Review. PubMed PMID: 31398275; PubMed Central PMCID: PMC6803038.
A Click Chemistry Approach Reveals the Chromatin-Dependent Histone H3K36 Deacylase Nature of SIRT7
W. W. Wang, M. Angulo-Ibanez, J. Lyu, Y. Kurra, Z. Tong, B. Wu, L. Zhang, V. Sharma, J. Zhou, H. Lin, Y. Q Gao, W. Li, K. F. Chua and W. R. Liu. "A Click Chemistry Approach Reveals the Chromatin-Dependent Histone H3K36 Deacylase Nature of SIRT7". J Am Chem Soc. 2019 Feb 13;141(6):2462-2473. doi: 10.1021/jacs.8b12083. Epub 2019 Feb 4. PubMed PMID: 30653310; PubMed Central PMCID: PMC6812484.
Estrogen Improves Insulin Sensitivity and Suppresses Gluconeogenesis via the Transcription Factor Foxo1
H. Yan, W. Yang, F. Zhou, X. Li, Q. Pan, Z. Shen, G. Han, A. Newell-Fugate, Y. Tian, R. Majeti, W. Liu, Y. Xu, C. Wu, K. Allred, C. Allred, Y. Sun and S. Guo. "Estrogen Improves Insulin Sensitivity and Suppresses Gluconeogenesis via the Transcription Factor Foxo1". Diabetes. 2019 Feb;68(2):291-304. doi: 10.2337/db18-0638. Epub 2018 Nov 28. PubMed PMID: 30487265; PubMed Central PMCID: PMC6341301.
2018
Structural insights into the π-π-π stacking mechanism and DNA-binding activity of the YEATS domain
B. J. Klein, K. R. Vann, F. H. Andrews, W. W. Wang, J. Zhang, Y.i Zhang, A. A. Beloglazkina, W. Mi, Y. Li, H. Li, X. Shi, A. G. Kutaeladze, B. Strahl, W. R. Liu and T. G. Kutateladze. "Structural Insights into the π-π-π Stacking Mechanism and DNA-binding Activity of the YEATS Domain", Nat Commun. 2018, Nov. 1; 9(1): 4574. doi:10.1038/s41467-018-07072-6. PubMed PMID: 30385749; PubMed Central PMCID: PMC6212594.
2018
Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome
B. T. Weinert, T. Narita, S. Satpathy, B, Srinivasan, B. K. Hansen, C. Schölz, W. B. Hamilton, B. E. Zucconi, W. W. Wang, W. R. Liu, J. M. Brickman, E. A. Kesicki, A. Lai, K. D. Bromberg, P. A. Cole, C. Choudhary. "Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome". Cell. 2018 Jun 28;174(1):231-244.e12. doi:
10.1016/j.cell.2018.04.033. Epub 2018 May 24. PubMed PMID: 29804834; PubMed Central PMCID: PMC6078418.
Incorporation of Nonproteinogenic Amino Acids in Class I and II Lantibiotics
N. Kakkar, J. G. Perez, W. R. Liu, M. C. Jewett, W. A. van der Donk. "Incorporation of Nonproteinogenic Amino Acids in Class I and II Lantibiotics". ACS Chem Biol. 2018 Apr 20;13(4):951-957. doi: 10.1021/acschembio.7b01024. Epub 2018 Feb 21. PubMed PMID: 29439566; PubMed Central PMCID: PMC5910287.
Using Amber and Ochre Nonsense Codons to Code Two Different Noncanonical Amino Acids in One Protein Gene
J. M. Tharp, W. R. Liu. "Using Amber and Ochre Nonsense Codons to Code Two Different Noncanonical Amino Acids in One Protein Gene". Methods Mol Biol. 2018;1728:147-154. doi: 10.1007/978-1-4939-7574-7_9. PubMed PMID: 29404996.10.1016/j.cell.2018.04.033. Epub 2018 May 24. PubMed PMID: 29804834; PubMed Central PMCID: PMC6078418.
A Lipid Transfer Protein Signaling Axis Exerts Dual Control of Cell-Cycle and Membrane Trafficking Systems
J. Huan, C. J. Mousley, L. Dacquay, N. Maitra, G. Drin, C. He, ND Ridgway, A. Tripathi, M. Kennedy, BK Kennedy, WS Liu, K. Baetz, M. Polymenis, V. A. Bankaitis. "A Lipid
Transfer Protein Signaling Axis Exerts Dual Control of Cell-Cycle and Membrane Trafficking Systems", Dev Cell. 2018 Feb 5; 44(3), 378-391.e5. doi: 10.1016/j.devcel.2017.12.026. Epub 2018 Jan 27. PubMed PMID: 29396115; PubMed Central PMCID: PMC6444186.
2017
2017
Evolving the N-Terminal Domain of Pyrrolysyl-tRNA Synthetase for Improved Incorporation of Noncanonical Amino Acids
Vangmayee Sharma, Yu Zeng, W. Wesley Wang, Yuchen Qiao, Yadagiri Kurra and Wenshe R. Liu*. "Evolving the N-Terminal Domain of Pyrrolysyl-tRNA Synthetase for Improved Incorporation of Noncanonical Amino Acids", ChemBioChem., 2017, 18, 1-6. doi:10.1002/cbic.201700268Transfer Protein Signaling Axis Exerts Dual Control of Cell-Cycle and Membrane Trafficking Systems", Dev Cell. 2018 Feb 5; 44(3), 378-391.e5. doi: 10.1016/j.devcel.2017.12.026. Epub 2018 Jan 27. PubMed PMID: 29396115; PubMed Central PMCID: PMC6444186.
A strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-orlistat hybrids
Mingzhao Zhu, Wayne D. Harshbarger, Omar Robles, Joanna Krysiak, Kenneth G. Hull, Sung Wook Chok, Robyn D. Richardson, Yanyan Yang, Andres Garcia, Lindsey Spiegelman, Bianca Ramirez, Christopher T. Wilson, Ju Anne Yau, James T. Moore, Caitlen B. Walker, James C. Sacchettini, Wenshe R. Liu, Stephan A. Sieber, Jeffrey W. Smith and Daniel Romo*. "A Strategy for Dual Inhibition of the Proteasome and Fatty Acid Synthase with Belactosin C-orlistat Hybrids", Bioorg. Med. Chem., 2017, 25, 2901-2916.
Genetically Encoded 2‑Aryl-5-carboxytetrazoles for Site-Selective Protein Photo-Cross-Linking
ulin Tian, Marco Paolo Jacinto, Yu Zeng, Zhipeng Yu, Jun Qu, Wenshe R. Liu and Qing Lin*, and Wenshe R. Liu*. "Genetically Encoded 2-Aryl-5-carboxytetrazoles for Site-Selective Protein Photo-Cross-Linking", J. Am. Chem. Soc., 2017, 139, 6078-6081.
A Versatile Approach for Site-Specific Lysine Acylation in Proteins
Zhipeng A. Wang, Yadagir Kurra, Xin Wang, Yu Zeng, Yan-Jiun Lee, Vangmayee Sharma, Hening Lin, Susie Y. Dai*, and Wenshe R. Liu*. "A Versatile Approach for Site-Specific Lysine Acylation in Proteins", Angew. Chem. Int. Ed., 2017, 56, 1643-1647.
A Genetically Encoded Allysine for the Synthesis of Proteins with Site-Specific Lysine Dimethylation
Zhipeng A. Wang, Yu Zeng, Yadagir Kurra, Xin Wang, Jeffrey M. Tharp, Erol C. Vatansever, Willie W. Hsu, Susie Dai, Xinqiang Fang,* and Wenshe R. Liu*. "A Genetically Encoded Allysine for the Synthesis of Proteins with Site-specific Lysine Dimethylation", Angew. Chem. Int. Ed., 2017, 56, 212-216.
2016
Probing the Catalytic Charge-Relay System in Alanine Racemase with Genetically Encoded Histidine Mimetics
Vangmayee Sharma, Yane-Shih Wang, and Wenshe R. Liu, "Probing the Catalytic Charge-Relay System in Alanine Racemase with Genetically Encoded Histidine Mimetics”, ACS Chem Biol. 2016, 11, 3305-3309.
2016
Genetically encoded fluorophenylalanines enable insights into the recognition of lysine trimethylation by an epigenetic reader
Yan-Jiun Lee, M. J. Schmidt, Jeffery M. Tharp, Annemarie Weber, Amber L. Koenig, Hong Zheng, Jianmin Gao, Marcey L. Waters, Daniel Summerer,* and Wenshe R. Liu* "Genetically Encoded Fluorophenylalanines Enable Insights into the Recognition of Lysine Trimethylation by an Epigenetic Reader" Chem. Commun., 2016, 52, 12606-12609.
Fluorinated Aromatic Amino Acids Distinguish Cation-π Interactions from Membrane Insertion*
He, Tao; Gershenson, Anne; Eyles, Stephen J.; Lee, Yan-Jiun; Liu, Wenshe R.; Wang, Jiangyun; Gao, Jianmin; and Roberts, Mary F.*, "Fluorinated Aromatic Amino Acids Distinguish Cation-π Interactions from Membran Insertion", J. Biol. Chem, 2015, 290, 19334-19342.
2015
A click chemistry approach to site-specific immobilization of a small laccase enables efficient direct electron transfer in a biocathode
Guan, Dongli; Kurra, Y; Liu, W. R.; Chen, Zhilei*, "A click chemistry approach to site-specific immobilization of a small laccase enables efficient direct electron transfer in a biocathode", Chem. Commun., 2015, 51, 2522-2525.
Expanding the chemical diversity of lasso peptide MccJ25 with genetically encoded noncanonical amino acids
Piscotta, Frank J.; Tharp, Jeffery M.; Liu, W. R.; Link, A. James*, "Expanding the chemical diversity of lasso peptide MccJ25 with genetically encoded noncanonical amino acids", Chem. Commun., 2015, 51, 409-412.
Wenshe Liu's Bibliography
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